2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 特許


  1. Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T, Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis. Hepatol Res. 45, 363-77, 2015
  2. Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T, Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis. J Gastroenterol. 50, 364-77, 2015
  3. Ishijima N, Kanki K, Shimizu H, Shiota G. AMPK activation by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib. Cancer Sci. 106, 567-75, 2015


  1. Itaba N, Wairagu PM, Aramaki N, Yasui T, Matsumi Y, Kono Y, Phan AN, Otsu M, Kunisada T, Nakamura Y, Okano H, Jeong Y, Shiota G. Nuclear receptor gene alteration in human induced pluripotent stem cells with hepatic differentiation propensity. Hepatol Res, 44, E408-19, 2014
  2. Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF Jr, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles. PLoS One. 9, e93579, 2014


  1. Kanki K, Akechi Y, Ueda C, Tsuchiya H, Shimizu H, Ishijima N, Toriguchi K, Hatano E, Endo K, Hirooka Y, Shiota G. Biological and clinical implications of retinoic acid-responsive genes in human hepatocellular carcinoma cells. J Hepatol. 59, 1037-44, 2013
  2. Shiota G, Kanki K. Retinoids and their target genes in liver functions and diseases. J Gastroenterol Hepatol. 28 Suppl 1:33-7. 2013
  3. Ebata Y, Takino J, Tsuchiya H, Sakabe T, Ikeda Y, Hama S, Kogure K, Takeuchi M, Shiota G, Presence of glyceraldehyde-derived Advanced glycation end-products in the liver of insulin-resistant mice. Int. J. Vitam. Nutr. Res. 83, 137-141, 2013
    Tsuchiya H, Ebata Y, Sakabe T, Hama S, Kogure K, Shiota G.  High-fat, high-fructose diet induces hepatic iron overload via a hepcidin-independent mechanism prior to the onset of liver steatosis and insulin resistance in mice. Metabolism. 62, 62-69, 2013
  4. Hoshikawa O, Ebata Y, Tsuchiya H, Kawahara A, Kojima C, Ikeda Y, Hama S, Kogure K, Shudo K, Shiota G. A retinoic acid receptor agonist tamibarotene suppresses iron accumulation in the liver. Obesity 21, E22-5, 2013
  5. Sakabe T, Tsuchiya H, Kanki K, Azumi J, Gonda K, Mizuta Y, Yamada D, Wada H, Shomori K, Nagano H, Shiota G, Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-α/5-fluorouracil and their clinical significance. PLoS One. 8, e56197, 2013


  1. Suzuki S, Kurata Y, Li P, Notsu T, Hasegawa A, Ikeda N, Kato M, Miake J, Sakata S, Shiota G, Yoshida A, Ninomiya H, Higaki K, Yamamoto K, Shirayoshi Y, Hisatome I. Stabilization of Kv1.5 channel protein by bepridil through its action as a chemical chaperone. Eur J Pharmacol. 696, 28-34, 2012
  2. Tsuchiya H, Ikeda Y, Ebata Y, Kojima C, Katsuma R, Tsuruyama T, Sakabe T, Shomori K, Komeda N, Oshiro S, Okamoto H, Takubo K, Hama S, Shudo K, Kogure K, Shiota G. Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice. Hepatology 56,1319-30, 2012
  3. Shiota G, Yasui T. Progress in stem cell biology in regenerative medicine for liver disease. Hepatol Res. 42, 15-21. 2012
    Shiota G, Yoshida Y. "Tet-On" system toward hepatic differentiation of human mesenchymal stem cells by hepatocyte nuclear factor. Methods Mol Biol. 826, 125-32, 2012
  4. Okamoto H, Matsumi Y, Hoshikawa Y, Takubo K, Ryoke K, Shiota G. Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS ONE. 7, e43800, 2012
  5. Itoh M, Tahimic CG, Ide S, Otsuki A, Sasaoka T, Noguchi S, Oshimura M, Goto YI, Kurimasa A. Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development. J Biol Chem. 287, 13859-67, 2012
  6. Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst). 11, 441-8, 2012


  1. Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Shiota G, Dong HH, Kim YB, Kaneki M. Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem. 286, 34959-75, 2011
  2. Ikeda R, Ishii K, Hoshikawa Y, Azumi J, Arakaki Y, Yasui T, Matsuura S, Matsumi Y, Kono Y, Mizuta Y, Kurimasa A, Hisatome I, Friedman SL, Kawasaki H, Shiota G. Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation. Inflamm Res. 60, 597-604, 2011
  3. Hoshikawa Y, Kanki K, Ashla AA, Arakaki Y, Azumi J, Yasui T, Tezuka Y, Matsumi Y, Tsuchiya H, Kurimasa A, Hisatome I, Hirano T, Fujimoto J, Kagechika H, Shomori K, Ito H, Shiota G. c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells. Cancer Sci. 102, 934-41, 2011
  4. Toyoda M, Kitaoka A, Machida K, Nishinakagawa T, Yada R, Kohjima M, Kato M, Kotoh K, Sakamoto N, Shiota G, Nakamuta M, Nakashima M, Enjoji M. Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes.Int J Mol Med. 27, 619-24, 2011
  5. Ting YK, Morikawa K, Kurata Y, Li P, Bahrudin U, Mizuta E, Kato M, Miake J, Yamamoto Y, Yoshida A, Murata M, Inoue T, Nakai A, Shiota G, Higaki K, Nanba E, Ninomiya H, Shirayoshi Y, Hisatome I. Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells. Br J Pharmacol. 162, 1832-42, 2011
    Nishio R, Tsuchiya H, Yasui T, Matsuura S, Kanki K, Kurimasa A, Hisatome I, Shiota G. Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd). Cancer Sci. 102, 622-9, 2011
  6. Hisatomi T, Sueoka-Aragane N, Sato A, Tomimasu R, Ide M, Kurimasa A, Okamoto K, Kimura S and Sueoka E. NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cellsby inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase. Blood 117, 3575-84, 2011
  7. Li, Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A, Mori S Ito H, Katoh M, Oshimura M, Inoue T. SIRT2 downregulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes to Cell 16, 34-45, 2011
  8. Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS and Chen BP. Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability. Radiat Res 175, 83-9, 2011
  9. Morita Y, Tsuchiya H, Harashima H, Kamiya H. Correction of frameshift mutations with tailed duplex DNAs. Biol Pharm Bull. 34, 1465-8. 2011


  1. Tsuchiya H, Sakabe T, Akechi Y, Ikeda R, Nishio R, Terabayashi K, Matsumi Y, Hoshikawa Y, Kurimasa A, Shiota G, A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet. Biol Pharm Bull. 33, 1101-4, 2010
  2. Tajima F, Tsuchiya H, Nishikawa K, Kataoka M, Hisatome I, Shiota G, Hepatocyte growth factor mobilizes and recruits hematopoietic progenitor cells into liver through a stem cell factor-mediated mechanism. Hepatol Res 40, 711-9, 2010
  3. Ashla AA, Hoshikawa Y, Tsuchiya H, Hashiguchi K, Enjoji M, Nakamuta M, Taketomi A, Maehara Y, Shomori K, Kurimasa A, Hisatome I, Ito H, Shiota G, Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease. Hepatol Res 40, 594-604, 2010
  4. Hashiguchi K, Tsuchiya H, Tomita A, Ueda C, Akechi Y, Sakabe T, Kurimasa A, Nozaki M, Yamada T, Tsuchida S, Shiota G. Involvement of ETS1 in thioredoxin-binding protein 2 transcription induced by a synthetic retinoid CD437 in human osteosarcoma cells. Biochem Biophys Res Commun 391, 621-6, 2010
  5. Tsuchiya H, Ashla AA, Hoshikawa Y, Matsumi Y, Kanki K, Enjoji M, Momosaki S, Nakamuta M, Taketomi A, Maehara Y, Shomori K, Kurimasa A, Hisatome I, Ito H, Shiota G, Iron state in association with retinoid metabolism in non-alcoholic fatty liver disease. Hepatol Res 40, 1227-1238, 2010


  1. Yamamoto Y, Matsuura T, Narazaki G, Sugitani M, Tanaka K, Maeda A, Shiota G, Sato K, Yoshida A, Hisatome I. Synergistic effects of autologous cell and hepatocyte growth factor gene therapy for neovascularization in a murine model of hindlimb ischemia. Am J Physiol Heart Circ Physiol, 297, H1329-1336, 2009
  2. Shiota G. Adiponectin as a therapeutic target of non-alcoholic steatohepatitis. Hepatol Res. 39, 951-3. 2009
    Takubo K, Tsuchiya H, Kurimasa A, Arnesen T, Ryoke K, Shiota G. Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. Anticancer Drugs. 20, 668-675, 2009
  3. Shiota G, Oyama K, Udagawa A, Nomi T, Tanaka K, Tsutsumi A, Noguchi N, Okano J, Kishimoto Y, Kanbe T, Kishimoto H, Kawasaki H. Partial analysis of hepatitis B virus DNA from hepatocellular carcinoma showing negative hepatitis B virus surface antigen: an analysis of two Japanese cases. Hepatogastroenterology. 56, 1516-1520, 2009
  4. Koshida S, Kurata Y, Notsu T, Hirota Y, Kuang TY, Li P, Bahrudin U, Harada S, Miake J, Yamamoto Y, Hoshikawa Y, Igawa O, Higaki K, Soma M, Yoshida A, Ninomiya H, Shiota G, Shirayoshi Y, Hisatome I. Stabilizing effects of eicosapentaenoic acid on Kv1.5 channel protein expressed in mammalian cells. Eur J Pharmacol. 604, 93-102, 2009
  5. Tsuchiya H, Akechi Y, Ikeda R, Nishio R, Sakabe T, Terabayashi K, Matsumi Y, Ashla AA, Hoshikawa Y, Kurimasa A, Suzuki T, Ishibashi N, Yanagida S, Shiota G. Suppressive effects of retinoids on iron-induced oxidative stress in the liver. Gastroenterology. 136, 341-350, 2009
  6. Sakamoto N, Ikeda K, Inada Y, Tojo K, Tajima N, Ishii K, Shiota G. Blockade of angiotension II type 1 receptor by telmisartan suppressed activation of human hepatic stellate cells. Ther Res 30, 1245-51, 2009
  7. Inoue T, Nakayama Y, Yamada H, Li YC, Yamaguchi S, Osaki M, Kurimasa A, Hiratsuka M, Katoh M, Oshimura M. SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. Cell Cycle. 8, 1279-91. 2009
  1. Yano S, Miake J, Mizuta E, Manabe K, Bahrudin U, Morikawa K, Arakawa K, Sasaki N, Igawa O, Shigemasa C, Yamamoto Y, Morisaki T, Hidaka K, Kurata Y, Yoshida A, Shiota G, Higaki K, Ninomiya H, Lee JK, Shirayoshi Y, Hisatome I. Changes of HCN gene expression and I(f) currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation. Biomed Res. 29, 195-20, 2008
  2. Matsuoka S, Tsuchiya H, Sakabe T, Watanabe Y, Hoshikawa Y, Kurimasa A, Harada T, Terakawa N, Masutani H, Yodoi J, Shiota G. Involvement of thioredoxin-binding protein 2 in the antitumor activity of CD437. Cancer Sci 99, 2485-90, 2008
  3. Ishii K, Yoshida Y, Akechi Y, Sakabe T, Nishio R, Ikeda R, Terabayashi K, Matsumi Y, Gonda K, Okamoto H, Takubo K, Tajima F, Tsuchiya H, Hoshikawa Y, Kurimasa A, Umezawa A, Shiota G. Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology. 48, 597-606, 2008
  4. Gonda K, Tsuchiya H, Sakabe T, Akechi Y, Ikeda R, Nishio R, Terabayashi K, Ishii K, Matsumi Y, Ashla AA, Okamoto H, Takubo K, Matsuoka S, Watanabe Y, Hoshikawa Y, Kurimasa A, Shiota G. Synthetic retinoid CD437 induces mitochondria-mediated apoptosis in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 370 ,629-33, 2008
  5. Inagaki Y, Higashi K, Kushida M, Hong YY, Nakao S, Higashiyama R, Moro T, Itoh J, Mikami T, Kimura T, Shiota G, Kuwabara I, Okazaki I. Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7. Gastroenterology. 134, 1180-90 , 2008
  6. Hoshiba T, Wakejima M, Cho CS, Shiota G, Akaike T. Different regulation of hepatocyte behaviors between natural extracellular matrices and synthetic extracellular matrices by hepatocyte growth factor. J Biomed Mater Res A. 85, 228-35, 2008
  7. Watanabe Y, Tsuchiya H, Sakabe T, Matsuoka S, Akechi Y, Fujimoto Y, Yamane K, Ikeda R, Nishio R, Terabayashi K, Ishii K, Gonda K, Matsumi Y, Ashla AA, Okamoto H, Takubo K, Tomita A, Hoshikawa Y, Kurimasa A, Itamochi H, Harada T, Terakawa N, Shiota G. CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling. Biochem Biophys Res Commun. 366, 840-7, 2008
  8. Murawaki Y, Tsuchiya H, Kanbe T, Harada K, Yashima K, Nozaka K, Tanida O, Kohno M, Mukoyama T, Nishimuki E, Kojo H, Matsura T, Takahashi K, Osaki M, Ito H, Yodoi J, Murawaki Y, Shiota G. Aberrant expression of selenoproteins in the progression of colorectal cancer. Cancer Lett. 259, 218-30. 2008
  9. Tsuchiya H, Uchiyama M, Hara K, Nakatsu Y, Tsuzuki T, Inoue H, Harashima H, Kamiya H. Improved gene correction efficiency with a tailed duplex DNA fragment. Biochemistry. 47, 8754-9. 2008


  1. Shimomura T, Yoshida Y, Sakabe T, Ishii K, Gonda K, Murai R, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, Hisatome I, Uyama T, Umezawa A, Shiota G. Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatol Res. 37, 1068-79, 2007
  2. Yoshida Y, Shimomura T, Sakabe T, Ishii K, Gonda K, Matsuoka S, Watanabe Y, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, Hisatome I, Uyama T, Terai M, Umezawa A, Shiota G. A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. Am J Physiol Gastrointest Liver physiol 293, 1736-40, 2007
  3. Ogura K, Miake J, Sasaki N, Iwai C, Bahrudin U, Li P, Kato M, Iitsuka K, Hirota Y, Koshida T, Yamamoto Y, Inoue Y, Yano A, Adachi M, Igawa O, Kurata Y, Morisaki T, Shiota G, Shirayoshi Y, Haruaki N, Hisatome I. Inhibition of beta-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells. J Mol Cell Cardiol. 43, 648-52, 2007
  4. Ichiba M, Yamada S, Ishii K, Gonda K, Murai R, Shimomura T, Saeki T, Kanbe T, Tanabe Y, Yoshida Y, Tsuchiya H, Hoshikawa Y, Kurimasa A, Kishimoto Y, Kawasaki H, Shiota G. Significance of urinary excretion of 8-hydroxy-2'-deoxyguanosine in healthy subjects and liver disease patients. Hepatogastroenterology. 54,1736-40, 2007
  5. Hara A, Yashima K, Yasugi A, Koda M, Kawaguchi K, Harada K, Andachi H, Shiota G, Ito H, Murawaki Y. Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype. Oncol Rep. 18, 553-9, 2007
  6. Murai R, Kanbe T, Mukoyama T, Shimomura T, Hashiguchi K, Yoshida Y, Tsuchiya H, Hoshikawa Y, Kurimasa A, Shiota G. Effect of rectal administration of rebamipide on dextran sulfate sodium-induced colitis: role of hepatocyte growth factor. Inflamm Res. 56, 240-5, 2007
  7. Shiota G. Role of retinoic acid receptor in steatohepatitis-related tumor formation. J Gastroenterol Hepatol. 22 Suppl 1:S101-7. 2007
  8. Sakabe T, Tsuchiya H, Endo M, Tomita A, Ishii K, Gonda K, Murai R, Takubo K, Hoshikawa Y, Kurimasa A, Ishibashi N, Yanagida S, Shiota G.An antioxidant effect by acyclic retinoid suppresses liver tumor in mice. Biochem Pharmacol. 73, 1405-11, 2007
  9. Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A. Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J Biol Chem. 282, 10138-45, 2007
  10. Kato H, Shimomura T, Murai R, Gonda K, Ishii K, Yoshida Y, Kanbe T, Hashiguchi K, Sakabe T, Takubo K, Okano J, Tsuchiya H, Hoshikawa Y, Kurimasa A, Shiota G. Regulation of hepatic oval cell proliferation by adenoviral mediated hepatocyte growth factor gene transfer and signal transduction inhibitors. Hepatogastroenterology. 54, 821-5, 2007
  11. Higashiyama R, Inagaki Y, Hong YY, Kushida M, Nakao S, Niioka M, Watanabe T, Okano H, Matsuzaki Y, Shiota G, Okazaki I. Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45, 213-22, 2007
  12. Nakatsuka R, Taniguchi M, Hirata M, Shiota G, Sato K. Transient expression of bone morphogenic protein-2 in acute liver injury by carbon tetrachloride. J Biochem. 141, 113-9, 2007


  1. Shiota G, Tsuchiya H. Pathophysiology of NASH: Insulin resistance, free fatty acids and oxidative stress. J Clin Biochem Nutr 38, 127-32, 2006
  2. Shiota G, Tsuchiya H, Hoshikawa Y. The liver as a target organ of retinoids. Hepatol Res. 36, 248-254, 2006
  3. Shiota G. The hypotheis of Warburg revisited: A metabolic switch in carcinogeneisis. Hepatol Res. 36, 156-7, 2006
  4. Sonoyama K, Ninomiya H, Igawa O, Kaetsu Y, Furuse Y, Hamada T, Miake J, Li P, Yamamoto Y, Ogino K, Yoshida A, Taniguchi S, Kurata Y, Matsuoka S, Narahashi T, Shiota G, Nozawa Y, Matsubara H, Horiuchi M, Shirayoshi Y, Hisatome I. Inhibition of inward rectifier K+ currents by angiotensin II in rat atrial myocytes: lack of effects in cells from spontaneously hypertensive rats. Hypertens Res. 29, 923-34, 2006
  5. Shiota G. A new way to cdeplete Kupffer cells. Hepatol Res. 36, 1-2, 2006
  6. Kanbe T, Murai R, Mukoyama T, Murawaki Y, Hashiguchi K, Yoshida Y, Tsuchiya H, Kurimasa A, Harada K, Yashima K, Nishimuki E, Shabana N, Kishimoto Y, Kojyo H, Miura K, Murawaki Y, Kawasaki H, Shiota G. Naked gene therapy of hepatocyte growth factor for dextran sulfate sodium-induced colitis in mice. Biochem Biophys Res Commun. 14, 345, 1517-25, 2006
  7. Saeki T, Ichiba M, Tanabe N, Ueki M, Okamoto K, Matsunaga Y, Hosho K, Kanbe T, Tsuchiya H, Kurimasa A, Yamada S, Hirooka Y, Hisatome I, Kishimoto Y, Suou T, Murawaki Y, Kawasaki H, Yodoi J, Shiota G. Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis. Liver International 26,157-165, 2006
  8. Tahimic CG, Tomimatsu N, Nishigaki R, Fukuhara A, Toda T, Kaibuchi K, Shiota G, Oshimura M, Kurimasa A.Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Biochem Biophys Res Commun. 340, 1244-50, 2006
  9. Gerweck LE, Vijayappa S, Kurimasa A, Ogawa K, Chen DJ.Tumor cell radiosensitivity is a major determinant of tumor response to radiation. Cancer Res. 66, 8352-5. 2006
  10. Sasaki S, Sato M, Katsura Y, Kurimasa A, Chen DJ, Takeda S, Kuwano H, Yokota J, Kohno T. Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells. Biochem Biophys Res Commun. 339, 583-90, 2006
  11. Ren X, Tahimic CG, Katoh M, Kurimasa A, Inoue T, Oshimura M. Human artificial chromosome vectors meet stem cells: new prospects for gene delivery. Stem Cell Rev. 2, 43-50, 2006


  1. Maeta Y, Shiota G, Okano J, Murawaki Y. Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells. Tumour Biol. 26, 300-5, 2005
  2. Shiota G, Loss of function of retinoic acid in liver leads to steatohepatitis and liver tumor: A NASH animal model. Hepatol Res 155-160, 2005
  3. Tanaka H, Miake J, Notsu T, Sonyama K, Sasaki N, Iitsuka K, Kato M, Taniguchi S, Igawa O, Yoshida A, Shigemasa C, Hoshikawa Y, Kurata Y, Kuniyasu A, Nakayama H, Inagaki N, Nanba E, Shiota G, Morisaki T, Ninomiya H, Kitakaze M, Hisatome I. Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine. Biochem Biophys Res Commun. 331, 1001-6, 2005
  4. Mukoyama T, Kanbe T, Murai R, Murawaki Y, Shimomura T, Hashiguchi K, Saeki T, Ichiba M, Yoshida Y, Tanabe N, Kurimasa A, Harada K, Yashima K, Hisatome I, Ito H, Murawaki Y, Shiota G. Therapeutic effect of adenoviral-mediated hepatocyte growth factor gene administration on TNBS-induced colitis in mice. Biochem Biophys Res Commun. 329, 1217-24, 2005
  5. Sonoyama K, Igawa O, Miake J, Yamamoto Y, Sugihara S, Sasaki N, Shimoyama M, Hamada T, Taniguchi S, Yoshida A, Ogino K, Shigemasa C, Hoshikawa Y, Kurata Y, Shiota G, Narahashi T, Horiuchi M, Matsubara H, Ninomiya H, Hisatome I. Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats. Hypertens Res. 28,173-9, 2005
  6. Ren X, Katoh M, Hoshiya H, Kurimasa A, Inoue T, Ayabe F, Shibata K, Toguchida J, Oshimura M. A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells. Stem Cells. 23,1608-16, 2005
  7. Otsuki A, Tahimic CG, Tomimatsu N, Katoh M, Chen DJ, Kurimasa A, Oshimura M. Construction of a novel expression system on a human artificial chromosome. Biochem Biophys Res Commun. 329,1018-25, 2005
  8. Tsuchiya H, Harashima H, Kamiya H. Factors affecting SFHR gene correction efficiency with single-stranded DNA fragment. Biochem Biophys Res Commun. 336, 1194-200, 2005
  9. Tsuchiya H, Sawamura T, Harashima H, Kamiya H. Correction of frameshift mutations with single-stranded and double-stranded DNA fragments prepared from phagemid/plasmid DNAs. Biol Pharm Bull. 28,1958-62, 2005
  10. Tsuchiya H, Harashima H, Kamiya H. Increased SFHR gene correction efficiency with sense single-stranded DNA. J Gene Med. 7,486-93, 2005
  11. Tsuchiya H, Matsuda T, Harashima H, Kamiya H. Cytokine induction by a bacterial DNA-specific modified base. Biochem Biophys Res Commun. 326, 777-81, 2005
  12. Tsuchiya H, Sawamura T, Uchiyama M, Harashima H, Kamiya H. Conversion of nucleotide sequence with single-stranded DNA fragment prepared from phagemid DNA. Nucleic Acids Symp Ser. 49, 93-4, 2005
  13. Kamiya H, Tsuchiya H, Harashima H. Newly Designed DNA Fragments for Gene Correction.In Non-viral Gene Therapy, Gene Design and Delivery 315-322, 2005
  14. Chikumi Y, Tajima F, Shiota G. The mechanism in hematopoietic stem cells/ progenitor cells mobilization. Recent Reseach Development in Haematology 2, 61-76. 2005


  1. 肝幹細胞の増殖方法、肝細胞の増殖方法及び肝幹細胞、汐田剛史、特願2002-303300号
  2. 免疫活性増強剤とこれを用いた免疫活性の増強、神谷浩之、原島秀吉、土谷博之、特願2003-431007号
  3. DNA塩基配列の変換方法、神谷浩之、原島秀吉、土谷博之、特願2004-034019号、PCT/JP2005/001991
  4. 末梢血中に造血幹細胞を動員するための肝細胞増殖因子(HGF)の使用と、この使用を目的とした医薬品、汐田剛史、但馬史人、特願2004-296763号
  5. ヒト幹細胞を肝細胞へと分化誘導する化合物、汐田剛史、森本稔、星川淑子、松本則子、松見吉朗、手塚祐太、アン アフィダ アスラ、新垣雄大、特願2010-092948号
  6. 5-FU単独及びIFN-α/5-FU併用時の抗腫瘍効果を増強する遺伝子群、汐田剛史、土谷博之、坂部友彦、特願2010-092869号、PCT/JP2011/059192
  7. レチノイン酸受容体リガンドの抗腫瘍作用、発癌抑制作用を含めた種々の作用を決定する遺伝子の同定、汐田剛史、明地雄司、上田知沙、土谷博之、特願2010-093226号
  8. レチノイン酸受容体リガンドによるインスリン抵抗性改善作用、汐田剛史、土谷博之、特願2010-093241号
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